Effect of Hyperoxia Solution on Anti-oxidative Damage and Clinical Observation on Patients with Acute Cerebral Infarction

Objective: To study the anti-oxidative damage effect of hyperoxia solution on patients with acute cerebral infarction.Method: 58 patients with acute cerebral infarction were randomly divided into hyperoxia solution therapy group and normal therapy control group.Each group was drawn blood and the SOD,MDA and NO concentration of blood plasma was measured according to the kit protocol before and 24h,48h after therapy.Meanwhile the clinical curative effect during the therapy was evaluated by the NDS standard.Result: The SOD concentration of blood plasma in hyperoxia solution therapy group remarkably rised and the MDA,NO concentration of blood plasma remarkably decreased after therapy.There was significant difference between the two group(P 0.05) in the concentration contrast of SOD,MDA,and NO during the therapy.The NSD score in hyperoxia solution therapy group was lower than the control group(P 0.05).Conclusion: Hyperoxia solution may relieve ischemical reperfusion injury in acute cerebral infarction by means of eliminating oxygen free radical and anti-oxidative damage.