Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Cerberus/Dand5 expression.

Cilia rotation-driven nodal flow is critical for the left-right (L-R) break in symmetry in most vertebrates. However, the mechanism by which the flow signal is translated to asymmetric gene expression has been insufficiently addressed. Here, we show that Hh signalling is asymmetrically activated (L