Genistein Improves the Major Depression through Suppressing the Expression of miR-221/222 by Targeting Connexin 43

Objective Recent studies have indicated the possibility that genistein may improve depression via regulating the expression of miR-221/222. This study is to explore whether genistein could improve depression by altering miR-221/222 levels and investigate the possible mechanisms involved in the improvement effect of genistein.