Comparative study of the gas transport characteristics of models of an extraerythrocyte oxygen carrier

It was shown that coupling of the 2,3-DPH functional analog, pyridoxal-5'-phosphate (PP) to hemoglobin (Hb) and its polymer (HbP) enables one to obtain an artificial oxygen carrier with gas transport characteristics similar to those of freshly prepared donor's blood. Coupling of PP to HB and HbP also intensifies their interaction with other physiologically important ligands (H+ and CO2) and changes the pattern of the relationship of P50 to the hemoprotein concentration in a solution.