Possible role of aphidicolin-sensitive DNA polymerase(s) in N-methyl-N'-nitro-N-nitrosoguanidine and bleomycin induced cellular repair synthesis and virus reactivation.

: Treatment of human embryonic cell line CLV 102 with N-methyl-N'-nitro-N-nitrosoguanidine or bleomycin was used to induce DNA repair synthesis. Both the repair synthesis induced by these agents and reactivation of UV-damaged pseudorabies virus were inhibited by aphidicolin.