SELDI Proteomics Approach to Identify Proteins Associated with T-Cell Clone Senescence

The immune system undergoes many complex changes as a result of the aging process. Elderly humans have altered cellular redox levels and deregulated immune responses, both key events underlying the progression of chronic degenerative diseases of aging, such as atherosclerosis and Alzheimer’s disease. T-cells are one of the major cell types affected by aging. As such, indentifying bio-markers of T-cell aging and senescence would aid in identifying and developing novel intervention strategies.