A Nonpeptidic Agonist Ligand of the Human C5a Receptor: Synthesis, Binding Affinity Optimization and Functional Characterization.

S.E. de Laszlo,Eric E. Allen,Bing Li,Debra L. Ondeyka,Ralph A. Rivero,Lorraine Malkowitz,C J Molineaux,Salvatore J. Siciliano,Martin S. Springer,William J. Greenlee,Nathan B. Mantlo

A Nonpeptidic Agonist Ligand of the Human C5a Receptor: Synthesis, Binding Affinity Optimization and Functional Characterization.

2010

S.E. de Laszlo
Eric E. Allen
Bing Li
Debra L. Ondeyka
Ralph A. Rivero
Lorraine Malkowitz
C J Molineaux
Salvatore J. Siciliano
Martin S. Springer
William J. Greenlee
Nathan B. Mantlo

The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.

Keywords:

C5a receptor
Stereochemistry
Ligand (biochemistry)
Agonist
Ligand
Chemistry
Organic chemistry

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