C-5a-substituted validamine type glycosidase inhibitors

Abstract A series of N -alkyl derivatives of the D-galactosidase inhibitor 1,4-di- epi -validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.