The effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder
2018
Objectives: Although cognitive behavioral therapy (CBT) is an effective treatment
for obsessive–compulsive disorder (OCD), the treatment mechanisms remain poorly
understood. This study aimed to investigate the effects of CBT on changes in the
intrinsic whole-brain functional network of OCD patients.
Materials and Methods: Twenty drug-naive and noncomorbid OCD patients were
recruited, and resting-state functional magnetic resonance imaging was performed
before and after 12 weeks of CBT. Moreover, 20 healthy controls were scanned
twice with a 12-week interval. A graph-theory degree centrality (DC) approach and
functional connectivity method were used to analyze the whole-brain functional
network hub and connectivity changes in OCD patients before and after CBT
treatment.
Results: A significant group × time interaction on DC was found in the left dorsolateral
prefrontal cortex (DLPFC); the DC in the left DLPFC was significantly reduced
after CBT treatment. Resting-state functional connectivity (RSFC) between the left
DLPFC and right orbitofrontal cortex was increased in the OCD patients at baseline,
and normalized after CBT treatment. RSFC changes between the left DLPFC and
default mode network (DMN) positively correlated with changes in clinical symptoms
in OCD patients.
Conclusions: These findings suggest that CBT can modulate changes in intrinsic
functional network hubs in the cortico–striato–thalamo-cortical circuit in OCD patients.
Cognitive control network and DMN connectivity may be a potential imaging
biomarker for evaluating CBT treatment for OCD.
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