Inhibitory Effect of a Potent and Selective Cytosolic Phospholipase A2α Inhibitor RSC-3388 on Skin Inflammation in Mice

Mina Yamamoto,Takayo Haruna,Kinichi Imura,Ichiro Hikita,Yoko Furue,Kenichi Higashino,Yoshinari Gahara,Masashi Deguchi,Kiyoshi Yasui,Akinori Arimura

Inhibitory Effect of a Potent and Selective Cytosolic Phospholipase A2α Inhibitor RSC-3388 on Skin Inflammation in Mice

2008

Mina Yamamoto
Takayo Haruna
Kinichi Imura
Ichiro Hikita
Yoko Furue
Kenichi Higashino
Yoshinari Gahara
Masashi Deguchi
Kiyoshi Yasui
Akinori Arimura

Cytosolic phospholipase A2α (cPLA2α) preferentially hydrolyzes membrane phospholipids containing arachidonic acid, resulting in the biosynthesis of eicosanoids such as prostaglan

Keywords:

Prostaglandin
Inflammation
Leukotriene
Biosynthesis
Phospholipase
Chemokine
Arachidonic acid
Chemistry
Chromatin structure remodeling (RSC) complex
Biochemistry
Cytosol

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