Anti Claudin3 monoclonal antibodies and cancer therapy and diagnosis using the same

Monoclonal antibodies are provided which specifically binds to Claudin3 expressed on the cell surface. Antibodies of the present invention are useful for the diagnosis of cancer Claudin3 is increased expression of ovarian cancer, prostate cancer, breast cancer, uterine cancer, liver cancer, lung cancer, pancreatic cancer, stomach cancer, bladder cancer, and the like colon cancer. The present invention has provided a monoclonal antibody exhibiting cytotoxic effect on these cancer cells. In other words, by contacting the antibody that binds to Claudin - expressing cells and Claudin -, methods and Claudin - expressing method of inhibiting the growth of cells causing cellular injury are disclosed Claudin - expressing cells. Furthermore, the present invention, diagnosis or treatment method for cancer is disclosed.