Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism.

Mechanistic links between cell autonomous clocks and metabolic processes remain largely unknown. The current study shows that cell autonomous clocks influence protein biotinylation, which in turn impacts fatty acid oxidation and protein synthesis. These observations may explain why disruption of circadian functions (e.g., shift workers) increases risk of cardiometabolic diseases.