3-(5,7-Dimethoxy-2,2-dimethyl-2H-benzo[b]pyran-6-yl)propionic acid: a potential inhibitor against Leishmania
2003
The title acid, C16H20O5, was extracted from Adiscanthus fusciflorus (Rutaceae) and is shown to inhibit adenine phosphoribosyltransferase (APRT) enzyme activity. This compound crystallizes in the centrosymmetric space group C2/c with one molecule in the asymmetric unit. There is one strong hydrogen bond, with OD⋯OA = 2.6238 (12) A and OD—H⋯OA = 171.1 (17)° involving the COOH group, forming a cyclic dimer about a center of symmetry. The packing of the molecules is additionally stabilized by one C—H⋯O [CD⋯OA = 2.9820 (16) A and CD—H⋯OA = 101.8 (10)°] and two C—H⋯π intermolecular hydrogen bonds.
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