Response to FSH of human Sertoli cells in culture

The study of the Sertoli cell was greatly enhanced by the setting up in the mid 1970s of methods for the separation and culture of these cells. Since then many aspects of Sertoli cell function have been delineated. The Sertoli cell is a target for both FSH and androgens, has a steroid metabolizing activity and secretes testis specific proteins, such as ABP and inhibin1, and also serum proteins2.