Cell Wall Targeted Antibiotics

The biosynthesis of murein occurs in three stages, which take place in (1) the cytoplasm forming muropeptide precursors, (2) the inner side of the cytoplasmic membrane involving the undecaprenyl-phosphate carrier lipid, and (3) the periplasm where the assembly of the macromolecule takes place. Antibiotics involved in the different steps of murein biosynthesis are described in this chapter.