Acute ischemic stroke presentation of otherwise asymptomatic covid-19 patient

Objective: Coronavirus disease 2019 (COVID-19), first identified in Wuhan, China in December 2019, become widespread and may be mortal, especially in some high-risk group Most of the reported experiences suggested that COVID-19 is associated with a distinct coagulation disorder resulting in fibrin thrombi within small vessels and capillaries Data focusing on arterial thrombotic events is few In milder COVID cases, both hemorrhagic and ischemic stroke may occur Acute ischemic stroke seems to be higher than the rate identified among patients who visited the emergency departments (ED) On the other hand, SARS-CoV-2 has the potential for neurotropism We here present a case who had neurological symptoms during pandemic days and has been diagnosed with imaging-proven ischemic stroke with COVID-19 Case report: A 40-year-old female patient presented to the ED with an articulation of speech and numbness in the right arm and leg She is not a smoker and denied any environmental exposure Physical examination revealed fever and hypotension with a respiratory rate was 18 breaths/min She had dysarthria, hypoesthesia, and frustrated hemiparesis on the right arm and leg Oxygen saturation was 98% on room air Mild normocytic anaemia and lymphopenia associated with a mild elevation in transaminases (AST 73 U/L, ALT 103 U/L) and in D-Dimer (1440 ng/ml) associated the clinical picture Thoracic CT showed bilateral multifocal peripheral ground glass infiltrations (Picture-1) Conventional MRI imaging is consistent with acute ischemia of millimetre in size on the left parietal lobe (Picture-2) The patient was accepted as having COVID-19 and acute ischemic stroke She commenced on hydroxychloroquine and azithromycin with enoxaparin Nasopharynx swab sample was found to be severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive by RT-PCR She did not progress to the hyperinflammation phase and discharged on 10th day of admission One month later on, outpatient visit her neurological findings resolved, no weakness was detected Conclusion: For each patient with an acute stroke clinic, thoracic CT and SARS-CoV-2 PCR should be performed before transferring to stroke or neurointensive care unit For our patient, she did not have apparent risk factors for stroke She was nearly asymptomatic apart of the stroke-related clinic, which points to the direct effect of coronavirus on vascular endothelial cells apart of the relationship between inflammation and coagulopathic complications in COVID-19