Динамика активности ферментов антирадикальной защиты у пациентов с сахарным диабетом и гипотиреозом при лечении препаратами липоевой кислоты

The article presents data reflecting the state of the enzyme level of the antioxidant system of blood in patients with diabetes mellitus (DM) and the traditional treatment of hypothyroidism and the use of drugs in the complex therapy of lipoic acid. From research that the enzyme pre-treatment performance level of antioxidant protection were reduced in the blood in diabetes and hypothyroidism, except for superoxide dismutase activity, increased by 18–21 % in patients with hypothyroid state. Such changes in the activity of enzymes antiradical defense led to the formation of oxidative stress, which was accompanied by an increase in the intensity of free radical processes in diabetes 1 type by 6,2 times, with diabetes 2 type by 3,5 times, decompensated hypothyroidism by 4.46 times. When using traditional treatment managed by 8–14 % increase in performance activity of catalase and superoxide dismutase in patients with diabetes, with decreased performance on chemiluminescence 20,5–56,8 % (p