DTIC Induces Damage in Melanoma DNA During Semi-Conservative DNA Synthesis

DTIC is an anti-neoplastic drug used in treatment of various malignant diseases such as lymphomas, sarcomas and melanomas. The mechanisms by which it exerts its cytotoxic effects is poorly understood although it is known that some of the metabolites formed from DTIC by liver microsomal enzymes exert cytotoxic functions (1–3).