Progress & prospect of metal-organic frameworks (MOFs) for enzyme immobilization (enzyme/MOFs)

Abstract Metal-organic frameworks (MOFs) have attracted tremendous interests of many researchers as a new kind of porous materials. Compared to conventional matrices, MOFs possess high surface area and porosity, thousands of various kinds and structures, abundant designable organic ligands and metal nodes. In recent years, more and more attention has been paid to using MOFs as the matrices for enzyme immobilization and different strategies have been explored extensively. To present a clear outline of this new field, this review systematically summarizes the progress of enzyme immobilization on MOFs (enzyme/MOFs) from different points, including various synthetic approaches, main characteristics, mechanism, improved performance and application of immobilized enzyme/MOFs. Finally, the prospect of enzyme/ MOFs is also discussed.