Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase

Introduction: We report a case of a newly diagnosed patient with chronic myeloid leukemia in chronic phase, with leukemic infiltration of the right ovary on disease presentation.Case report: The patient presented with abdominal pain, leukocytosis, and anemia. Peripheral blood smear was indicative of chronic myloid leukemia and cytoreductive treatment was started. Due to the worsening of the abdominal pain, a computerized tomography was done. It revealed a cystic tumor of the right ovary. The tumor was surgically removed. Bone marrow examination confirmed the diagnosis of chronic myloid leukemia in chronic phase. Immunohistochemical analysis of the ovarian tumor showed leukemic infiltration with 5% of blasts. The patient was treated with imatinib for one year. Due to treatment failure, imatinib was switched to nilotinib. Allogeneic stem cell transplantation is considered. Conclusion: This case points out the critical role of multidisciplinary team approach and close treatment monitoring to achieve the best possible outcome.