Liver regeneration after major liver hepatectomy: Impact of body mass index

Background Obese patients may present with metabolic abnormalities that impact liver regeneration. We sought to assess the impact of body mass index (BMI) on liver volume regeneration index (RI) and kinetic growth rate (KGR) among patients undergoing liver resection. Methods The study included 102 patients undergoing major hepatectomy (≥3 segments) between July 2004 and April 2015 and stratified the patients by preoperative BMI, number of segments resected, and postoperative remnant liver volume (RLV p ) to total liver volume ratio. Resected volume at operation was subtracted from total liver volume to calculate postoperative RLV p . RI was defined as the relative increase in RLV within 2 months [(RLV 2m –RLV p )/RLV p ] and 7 months [(RLV 7m –RLV p )/RLV p ] postoperatively; KGR was calculated as RI divided by time postoperatively (weeks). Results Median patient age was 59.6 years (interquartile range 48.1–68.7 years), and most patients were men (52.0%). Liver failure was associated with the KGR at 2 months (KGR 2m ) and was greater among patients with KGR 2m P  = .04). Although RI and KGR within 2 and 7 months postoperatively were similar among all patients, after excluding patients with fibrosis, obese (0.42% per week) and overweight patients (0.29% per week) had lesser KGR 2–7m compared with patients of normal BMI (0.82% per week; P P  = .04). Conclusion BMI did not impact liver regeneration during the first 2 months. In contrast, KGR per week between 2 and 7 months postoperatively was less among overweight and obese patients.