Molecular Pathogenesis and Treatment Approaches of COVID-19 – A Comprehensive Review

An outbreak of “Pneumonia of Unknown Etiology” occurred in Wuhan, China in late December 2019. Later the agent factor was identified and coined as SARS-COV-2 and the disease was named as coronavirus disease 2019 (COVID-19). In a shorter period, this newly emergent infection bought the world into a standstill. On 11th March 2020, WHO declared COVID-19 as a pandemic. The researchers across the globe have joined their hands to investigate about SARSCoV2 in terms of pathogenicity, transmissibility and deduce therapeutics to subjugate this infection. T The researchers and scholars practicing different art of medicine are into an extensive quest to come up with safer ways to curb the pathological implications of this viral infection. A huge number of clinical trials are underway from the branch of allopathy and naturopathy in this regard. Besides, a paradigm shift on cellular therapy and nano-medicine protocols have to be optimized for better clinical and functional outcome of COVID-19 affected individuals. This article unveils a comprehensive review of the pathogenesis, mode of spread and various treatment modalities to combat COVID-19 disease. Funding: National Natural Science Foundation of China. Conflict of Interest: We declare no competing interests.