Aryl sulfones : A new class of γ-secretase inhibitors

Martin Richard Teall,Paul Joseph Oakley,Timothy Harrison,Duncan Shaw,Euan R. Kay,Jason Matthew Elliott,Ute Gerhard,José L. Castro,Mark S. Shearman,Richard G. Ball,Nancy N. Tsou

Aryl sulfones : A new class of γ-secretase inhibitors

2005

Martin Richard Teall
Paul Joseph Oakley
Timothy Harrison
Duncan Shaw
Euan R. Kay
Jason Matthew Elliott
Ute Gerhard
José L. Castro
Mark S. Shearman
Richard G. Ball
Nancy N. Tsou

Abstract The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer’s disease is described.

Keywords:

Amyloid precursor protein secretase
Enzyme
Chemical synthesis
Aryl
Amyloid precursor protein
Alzheimer's disease
Stereochemistry
Biochemistry
Sulfone
Chemistry
Enzyme inhibitor
Biological activity

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations