Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection

Vikas Gautam,Johan W. Mouton,Marian T. ten Kate,Irma A. J. M. Bakker-Woudenberg,Sebastian van Burgh,Nikolaos Strepis,Corné H. W. Klaassen,Wil H. F. Goessens

Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection

2019

Vikas Gautam
Johan W. Mouton
Marian T. ten Kate
Irma A. J. M. Bakker-Woudenberg
Sebastian van Burgh
Nikolaos Strepis
Corné H. W. Klaassen
Wil H. F. Goessens

Background: Fourth-generation cephalosporins have been developed to improve their potency, that is, low minimal inhibitory concentrations (MICs) and to prevent resistance selection of derepressed A...

Keywords:

Virology
Klebsiella pneumoniae
Microbiology
Cefpirome
Enterobacter cloacae
Biology
Mutant
treatment results
Potency
pulmonary infection
Cephalosporin

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