Glomerular Basement Membrane Antigens in Various Renal Diseases in Childhood

Urinary glomerular basement membrane (GBM) antigens were determined by radioimmunoassay in children with various glomerular diseases. The excretion of the GBM protein antigens was about one mg/g of urinary protein in most patients, except for patients with minimal change nephrosis. Although the GBM antigens were not uniform substances, the excretion of the GBM glycoprotein antigens was greatest in patients with membranoproliferative glomerulonephritis and rapidly progressive glomerulonephritis.