Method for synthesizing DL-serine through enzyme catalysis method

2013 
The present invention relates to a method for synthesizing DL-serine through an enzyme catalysis method. According to the method, formaldehyde and glycine are adopted as substrates, in the presence of coenzyme and under an effect of a catalyst having serine hydroxymethyl transferase activity or D-threonine aldolase activity, one molecule of the formaldehyde and one molecule of the glycine are converted into one molecule of the single configuration serine, and racemization is performed under an effect of a catalyst having amino acid racemase activity to produce DL-serine, wherein preferably the whole enzyme catalysis reaction process is added with the cofactor so as to promote the enzyme catalysis reaction process. The method has advantages of clever design, simple operation, short production cycle, low production cost, high yield, low environmental protection pressure and the like, and is suitable for large-scale industrial production.
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