Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats.

ObjectivesAldosterone is well recognized as the selective physiological ligand for mineralocorticoid receptor in epithelia. However, in-vitro studies have demonstrated that the affinity of aldosterone and glucocorticoids for mineralocorticoid receptor is similar. We hypothesized that glucocorticoids