Association between age, gender, residential region, and prevalence of subependymal giant cell astrocytoma among patients with tuberous sclerosis complex: A U.S. Healthcare Claims Database study.

1609 Background: Subependymal giant-cell astrocytomas (SEGA) are slow growing non-cancerous tumors that can occur in patients with tuberous sclerosis complex (TSC). The objectives of this study were to examine SEGA prevalence among TSC patients in a real world setting, and to ascertain the relationships between SEGA prevalence and age groups, genders, or residential regions. Methods: We conducted a retrospective cohort study based on a large US commercial healthcare claims database. Patients with a TSC claim between 2000 and 2009 and with 12-month continuous enrollment after their first TSC claim were included into the study. SEGA was identified based on ICD-9CM codes in inpatient or outpatient claims. Patients’ genders, residential regions and ages of their first TSC claim and /or their first SEGA claim (if they had SEGA) were extracted from enrollment files respectively. SEGA prevalence was assessed with subgroup analyses of genders, age groups of first TSC claim, and residential regions. Two-sample t t...