15N NMR shifts for imidazole and 1-methyl imidazole in CH2Cl2 relative to aqueous solution☆

Abstract The 15 N NMR frequencies for imidazole nitrogens undergo significant shifts when imidazole or 1-methyl imidazole is taken from aqueous to CH 2 Cl 2 solution. This shift is probably primarily due to strong hydrogen-bonding between 15 N 3 of imidazole and H 2 O protons in aqueous solution.