Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes (292.2)

Toshiyuki Kudo,Akihiro Hisaka,Yuchi Sugiyama,Kiyomi Ito

Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes (292.2)

2014

Toshiyuki Kudo
Akihiro Hisaka
Yuchi Sugiyama
Kiyomi Ito

The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole (ICZ) and gemfibrozil (GEM). The present study analyzed this in...

Keywords:

Endocrinology
Itraconazole
Enzyme
Internal medicine
Gemfibrozil
Biology
Repaglinide
Non-competitive inhibition
Physiologically based pharmacokinetic modelling
Oral administration
Pharmacokinetics
Glucuronide
Pharmacology
Organic anion-transporting polypeptide

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