skin Tightening Effect Using Fractional Laser Treatment Ii: A Pilot Animal Study on Skin Remodeling

BACKGROUND Fractional laser resurfacing is a new procedure for skin rejuvenation. We have found that it has a skin tightening effect in humans. OBJECTIVE To assess the mechanism of the skin tightening effect of fractional laser treatment in animals using histologic approaches. METHODS The dorsal skin of hairless guinea pigs was irradiated with a fractional 1,540-nm erbium glass laser. Biopsy specimens were taken serially from 0 hour until 1 year after irradiation and evaluated histologically. RESULTS Histologic evaluation indicated dermal remodeling within 2 months, in which regenerated collagen bundles and fibroblasts aligned in a horizontal direction, suggesting a traction stress on the dermal components. The treated part became less obvious over a period of more than 3 months by recovery of fine collagen bundles without fibrosis. CONCLUSION These results suggest that improvement of the tension in a horizontal direction is essential for skin remodeling and improvement of facial laxity using fractional laser resurfacing. The authors have indicated no significant interest with commercial supporters.