Análise teórica da atuação de canabinoides nas vias metabólicas do câncer de mama por meio da biologia de sistemas e revisão sistemática da literatura

Breast cancer is the most common and incident kind of tumor. Despite the significative advances on treatment, there are gaps regarding the understanding of the therapy resistance mechanisms. The cannabinoids have shown considerable activity in breast tumors treatment of both in vitro and in vivo. Given the heterogenic profile of this kind of tumor, and the complexity of the therapeutical potential of the cannabinoids, it is necessary to identify the acting metabolic pathways of these compounds for the development of medicines to treat diseases like breast cancer. In this paper, through a systematic literature review and data obtained at the StringDB database, it was aimed to explain the role of the cannabidiol cannabinoid on MDA-MB-231 breast cancer cells. It was found that the classic JAK-STAT pathway can be crucial for cannabidiol acting on breast cancer, knowing that the STAT3 protein can be activated through G-protein coupled receptors, which are a negative allosteric modulation target from cannabidiol. It was concluded that the cannabidiol’s effect on its respective receptor can promote their modulation and, as consequence, the non-activation of STAT3.