Blood pressure and heart rate measures: How well do pre-clinical models translate? (681.7)

Within research, animal models are commonly used to examine the physiology of disease, and evaluate the efficacy and safety of drugs. However, understanding of the translation of cardiovascular (CV) endpoints [specifically, heart rate (HR) and blood pressure (BP)] from pre-clinical animal studies to the clinic is still limited. Internal databases containing BP and HR data from a broad range of compounds evaluated in pre-clinical CV safety pharmacology animal models and Phase 1 human clinical trials were used to evaluate the translation across pre-clinical findings from rodent (rat) to large animal (non human primate and dog), as well as the translation of findings from pre-clinical animal models to humans. The database currently consists of >700 historical preclinical CV safety pharmacology studies and represents experiments across 5 species. The analysis of this information has indicated that many mechanisms modulate blood pressure and heart rate, further demonstrating the complexity of CV system. Moreov...