Research progression on application of small molecular targeted drugs for pancreatic cancer

Pancreatic cancer has features of hidden onset,difficult diagnosis at early stage,high malignant degree,high mortality,its incidence has a rising trend globally.The cytotoxic drugs such as gemcitabine are still the mainstream standard chemotherapy drugs for pancreatic cancer treatment,but the efficacy is not ideal.Seeking new targeted therapy and studying targeted drugs in combination with cytotoxic drugs to improve treatment effect and the quality of life is the current concerned direction.This article is going to introduce the targeted drugs which has positive results in treatment of pancreatic cancer in recent years,it illustrates the research progress on the mechanism of action of targeted drugs according to the properties of molecular targeted spots. Key words: Pancreatic cancer;  Gemcitabine;  Small molecular targeted drugs