A three-step synthesis of a glitoxin analogue with anti-reverse transcriptase activity

Henricus C. J. Ottenheijm,Gerardus P. C. Kerkhoff,Johannes W. H. A. Bijen,Tom F. Spande

A three-step synthesis of a glitoxin analogue with anti-reverse transcriptase activity

1975

Henricus C. J. Ottenheijm
Gerardus P. C. Kerkhoff
Johannes W. H. A. Bijen
Tom F. Spande

A practical, 3-step synthesis of general applicability to analogues of gliotoxin has been devised and used to prepare the potent antiviral compound (12) in 37% yield.

Keywords:

Chemistry
Combinatorial chemistry
Gliotoxin
Organic chemistry
Reverse transcriptase activity
Reverse transcriptase

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