Comparative analysis of tumour angiogenesis in solid multicystic and unicystic ameloblastoma by using CD 105 (endoglin)

Abstract Objective The aim of the present study was to evaluate and compare the expression of CD105 (endoglin) in solid multicystic ameloblastoma (SMA) and unicystic ameloblastoma (UA). Materials and methods Angiogenesis was assessed in 20 SMA, 15 UA and 10 normal oral mucosa samples by measuring the mean vascular density (MVD), total vascular area (TVA) and mean vascular area (MVA). The immunohistochemistry was carried out by using monoclonal mouse anti-human antibody against CD105. Results The Kruskal–Wallis test showed significant difference in mean MVD, TVA, and MVA between SMA, UA, and control group ( p p p p  > 0.05). Conclusion Our study results show no significant difference in MVD, TVA and MVA between SMA and UA. This may reflect the fact that though clinical behaviour, histopathological presentation and prognosis of SMA and UA differ, the process of angiogenesis is not different. This suggests that the angiogenesis has an important role in tumour progression and invasiveness of ameloblastoma. Measurement and assessment of tumour angiogenesis may prove very valuable in predicting response to antiangiogenic therapeutic strategies and also provide objective assessment of post therapeutic response particularly in recurrent cases of SMA and UA.