Meta-analysis assessment of GP210 and SP100 for the diagnosis of primary biliary cirrhosis.

Abstract Purpose:To conduct a systematic review of included studies assessing the association of GP210 and SP100 with the risk ofprimary biliary cirrhosis (PBC) using meta-analysis.Methods:Five databases, the Cochrane Library, MEDLINE, VIP, CNKI, WANFANG were used to detect the role of GP210 andSP100 in diagnosis of PBC. Approximately 13,000 participants from several countries were included in this analysis. Meta-DiSc statistical software was used for analysis.Results:25 studies on GP210 and 21 studies on SP100 were included in the meta-analysis. The DOR, sensitivity, specificity ofGP210 in diagnosis of PBC were 24.854 (11.957–51.660), 0.272 (0.257–0.288), 0.985 (0.982–0.988), respectively, and they were9.133 (4.739–17.600), 0.231 (0.213–0.249), 0.977 (0.973–0.981) for SP100.Conclusion:Our meta-analysis indicated both GP210 and SP100 had high specificity but low sensitivity in diagnosis of PBC. Citation: Hu S-L, Zhao F-R, Hu Q, Chen W-X (2014) Meta-Analysis Assessment of GP210 and SP100 for the Diagnosis of Primary Biliary Cirrhosis. PLoS ONE 9(7):e101916. doi:10.1371/journal.pone.0101916Editor: Robert Lane Schmidt, University of Utah School of Medicine, United States of AmericaReceived March 20, 2014; Accepted June 10, 2014; Published July 10, 2014Copyright: 2014 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All data in the meta-analysis are frompublished studies, and the DOIs for each paper are included in the references.Funding: The reported work was supported by research grants from National Natural Science Foundation of China (81171628). The website is https://isis.nsfc.gov.cn/egrantweb/. WXC received the funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of themanuscript.Competing Interests: The authors have declared that no competing interests exist.* Email: chenweixian75@163.comThese authors are the joint first authors on this work.