Компьютерный анализ зависимости структура - активность производных тиазоло[3,2-a]бензимидазола с бронхолитическим действием

Computer-aided analysis of the Structure - Activity Relationship and purposeful Design (SARD) of effective bronchodilators in a series of thiazolo[3,2-a]benzimidazole derivatives have been carried out. The reliability of the created mathematical model is 76 - 81%, as determined by the level of recognition of the active and inactive «learning» structures with respect to the property under consideration, and depends on the particular group of compounds and the employed algorithm. The results of the forecast well agree with the experimental data: almost all (~90 %) of tested thiazolo[3,2-a]benzimidazole derivatives showed the predicted activity.