Estradiol, androstenedione, testosterone, and dehydroepiandrosterone sulfate in the ovarian and peripheral blood of postmenopausal patients with and without endometrial cancer

Abstract Estradiol (E), androstenedione (A), testosterone (T), and dehydroepinadrosterone sulfate (DHEAS) were determined in the plasma taken from the ovarian and cubital vein in endometrial cancer patients and controls. All the cases and controls experienced their menopause more than 4 years before the study. The patients were matched for weight and height. No difference was found for T, A, and DHEAS in the peripheral blood between cases and controls. Nevertheless a statistically significant difference was observed for T and A, higher in the cases than in the controls: 4.38 ± 1.32 vs 1.38 ± 0.51, for T and 5.69 ± 1.65 vs 2.57 ± 0.12 for A. Estradiol was higher in peripheral and ovarian blood of cancer cases when compared with the controls but the difference is not statistically significant.