Exosomal miR-155 Derived from Hepatocellular Carcinoma Cells Under Hypoxia Promotes Angiogenesis in Endothelial Cells

Yusuke Matsuura,Hiroshi Wada,Hidetoshi Eguchi,Kunihito Gotoh,Shogo Kobayashi,Mitsuru Kinoshita,Masahiko Kubo,Koji Hayashi,Yoshifumi Iwagami,Daisaku Yamada,Tadafumi Asaoka,Takehiro Noda,Koichi Kawamoto,Yutaka Takeda,Masahiro Tanemura,Koji Umeshita,Yuichiro Doki,Masaki Mori

Exosomal miR-155 Derived from Hepatocellular Carcinoma Cells Under Hypoxia Promotes Angiogenesis in Endothelial Cells

2019

Yusuke Matsuura
Hiroshi Wada
Hidetoshi Eguchi
Kunihito Gotoh
Shogo Kobayashi
Mitsuru Kinoshita
Masahiko Kubo
Koji Hayashi
Yoshifumi Iwagami
Daisaku Yamada
Tadafumi Asaoka
Takehiro Noda
Koichi Kawamoto
Yutaka Takeda
Masahiro Tanemura
Koji Umeshita
Yuichiro Doki
Masaki Mori

Purpose In this study, we aim to clarify whether exosomes secreted from hepatocellular carcinoma (HCC) cells under hypoxia affect angiogenesis in endothelial cells.

Keywords:

Medicine
Endocrinology
Microvesicles
Hypoxia (medical)
Angiogenesis
Internal medicine
Hepatocellular carcinoma
Cancer research
Exosome
miR-155
Gene knockdown
tube formation
Cell culture

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