2-acylaminothiazole derivatives or salts thereof

The present inventors have found that a substituted muscarinic M3 receptor positive allosteric modulators that thiazole derivatives superior was pyrazine-2-carbonylamino second place, the bladder and urinary tract diseases bladder contractions due to muscarinic M3 receptor is involved the present invention has been completed by finding that it is useful as a preventive and / or therapeutic agents. 2-acylaminothiazole derivatives or salts thereof of the present invention may be used as a prophylactic and / or therapeutic agent for bladder contractions due to muscarinic M3 receptors bladder and urinary tract diseases associated with, for example, dysuria such as hypoactive bladder . (In the formula, R R R R R )