원저 : 삼수 난소적출로 유발된 흰쥐의 골다공증에 미치는 영향

Objectives : The present study has been undertaken to investigate the effects of and Ginseng Radix Palva on osteoporosis in ovariectomized rats. Methods : In this expaiment, the rats were ovariectomihed. Rats were administered by 2 kinds of medicine, Estradiol and Ginseng Radix Palva. The levels of bone mineral density, osteocalcin, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. results : The levels of bone mineral density were not significantly increased in comparison with OVX group in Ginseng Radix Palva group. The levels of serum didn`t show significant change in comparison with OVX group in Ginseng Radix Palva group. The levels of urine deoxypyridinoline didn`t show significant decrease in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial ash weight didn`t show significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of femoral and fibula-tibial phosphorus showed significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of body weight didn`t show significant changes in comparison with OVX group in Ginseng Radix Palva group. The levels of uterus weight didn`t show significant changes in comparison with OVX group in Ginseng Radix Palva group. Conclusions : Reviewing these experimental results, it appears that Ginseng Radix Palva have efficacy on osteoporosis. And further study should be conducted to illustrate in depth the curing osteoporosis.