Stereoselective Synthesis of Unsaturated Polyhydroxylated Amino Acids via Ester Enolate Claisen Rearrangement

Ester enolate Claisen rearrangement of chelated N-protected chiral allylic amino acid esters results in the formation of polyhydroxylated γ,δ-unsaturated amino acids in good yields and with a high degree of chirality transfer.