A CASE OF RHABDOMYOLYSIS AND MULTIPLE ORGAN FAILURE DUE TO DRUG INTOXICATION

A case of drug intoxication, which caused rhabdomyolysis of the left extremities, multiple organ failure including renal failure, DIC, and ARDS, and systemic metabolic disorder, was experienced. For local lesions, surgical treatment with fasciotomy was performed, and for renal failure, hypermyoglobinemia, and systemic metabolic disorder, blood purification was done. It took for 52 days and 61 days to normalize the oxygenizing potential and to be freed from blood purification, respectively. On 90th hospital day paralysis disappeared and surgical wounds were closed. On 110th day symptomatic remission was attained and the patient was discharged from the hospital. At etiology of this disease, possible contribution of chemical mediators released with reperfusion after ischemia is thought. Accordingly, in the treatment of this disease, local proper treatments as well such treatments considering chemical mediator strategy as blood purification methods and administration of proteinase inhibitors are necessary.