Xilobam: Analysis, determination of decomposition products, and assessment of stability
1981
Abstract A stability-indicating UV assay was developed for xilobam, a member of a new class of CNS agents. The method was specific, precise, and accurate. TLC and high-pressure liquid chromatography were used to support method specificity. Xilobam is sensitive to heat, moisture, and basic conditions. The degradation products were identified as N -methylpyrrolidone, 2, 6-dimethylaniline, and N , N ′-bis(2, 6-dimethylphenyl)urea. At high temperatures, the incorporation of molecular sieves into glass bottles of xilobam tablets was effective in preventing decomposition caused by moisture or volatile decomposition products.
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