Ceftiofur Crystalline Free Acid Sterile Suspension (CCFA-SS) in Cattle:

Ceftiofur, a time-dependent, bactericidal antibiotic active against bovine respiratory disease pathogens, is effective when the concentrations remain above the minimum inhibitory concentration (MIC) for at least 3-5 days. A new product, CCFA-SS, is a prolonged release formulation of ceftiofur, intended to provide single dose efficacy in cattle. It is administered subcutaneously (SC) in the ear, eliminating any injection in edible tissue. The objective of this study was to generate plasma ceftiofur concentration data following administration of CCFA-SS SC in the middle third of the posterior aspect of the ear.