New gene functions in megakaryopoiesis and platelet formation

Christian Gieger,Aparna Radhakrishnan,Ana Cvejic,Weihong Tang,Eleonora Porcu,Giorgio Pistis,Jovana Serbanovic-Canic,Ulrich Elling,Alison H. Goodall,Yann Labrune,Lorna M. Lopez,Reedik Mägi,Stuart Meacham,Yukinori Okada,Nicola Pirastu,Rossella Sorice,Alexander Teumer,Katrin Voss,Weihua Zhang,Ramiro Ramirez-Solis,Joshua C. Bis,David Ellinghaus,Martin Gögele,Jouke-Jan Hottenga,Claudia Langenberg,Peter Kovacs,Paul F. O'Reilly,So-Youn Shin,Tõnu Esko,Jaana Hartiala,Stavroula Kanoni,Federico Murgia,Afshin Parsa,Jonathan Stephens,Pim van der Harst,C. Ellen van der Schoot,Hooman Allayee,Antony Attwood,Beverley Balkau,François Bastardot,Saonli Basu,Sebastian E. Baumeister,Ginevra Biino,Lorenzo Bomba,Amélie Bonnefond,François Cambien,John Chambers,Francesco Cucca,Pio D’Adamo,Gail Davies,Rudolf A. de Boer,Eco J. C. de Geus,Angela Döring,Paul Elliott,Jeanette Erdmann,David Evans,Mario Falchi,Wei Feng,Aaron R. Folsom,Ian H. Frazer,Quince Gibson,Nicole L. Glazer,Christopher J. Hammond,Anna-Liisa Hartikainen,Susan R. Heckbert,Christian Hengstenberg,Micha Hersch,Thomas Illig,Ruth J. F. Loos,Jennifer Jolley,Kay-Tee Khaw,Brigitte Kühnel,Marie-Christine Kyrtsonis,Vasiliki Lagou,Heather Lloyd-Jones,Thomas Lumley,Massimo Mangino,Andrea Maschio,Irene Mateo Leach,Barbara McKnight,Yasin Memari,Braxton D. Mitchell,Grant W. Montgomery,Yusuke Nakamura,Matthias Nauck,Gerjan Navis,Ute Nöthlings,Ilja M. Nolte,David J. Porteous,Anneli Pouta,Peter P. Pramstaller,Janne Pullat,Susan M. Ring,Jerome I. Rotter,Daniela Ruggiero,Aimo Ruokonen,Cinzia Sala,Nilesh J. Samani,Jennifer Sambrook,David Schlessinger,Stefan Schreiber,Heribert Schunkert,James Scott,Nicholas L. Smith,Harold Snieder,John M. Starr,Michael Stumvoll,Atsushi Takahashi,W.H. Wilson Tang,Kent D. Taylor,Albert Tenesa,Swee-Lay Thein,Anke Tönjes,Manuela Uda,Sheila Ulivi,Dirk J. van Veldhuisen,Peter M. Visscher,Uwe Völker,H.-Erich Wichmann,Kerri L. Wiggins,Gonneke Willemsen,Tsun-Po Yang,Jing Hua Zhao,Paavo Zitting,John R. Bradley,George Dedoussis,Paolo Gasparini,Stanley L. Hazen,Andres Metspalu,Mario Pirastu,Alan R. Shuldiner,L. Joost van Pelt,Jaap Jan Zwaginga,Dorret I. Boomsma,Ian J. Deary,Andre Franke,Philippe Froguel,Santhi K. Ganesh,Marjo-Riitta Järvelin,Nicholas G. Martin,Christa Meisinger,Bruce M. Psaty,Tim D. Spector,Nicholas J. Wareham,Jan Willem N. Akkerman,Marina Ciullo,Panos Deloukas,Andreas Greinacher,Steve Jupe,Naoyuki Kamatani,Jyoti Khadake,Jaspal S. Kooner,Josef M. Penninger,Inga Prokopenko,Derek L. Stemple,Daniela Toniolo,Lorenz Wernisch,Serena Sanna,Andrew A. Hicks,Augusto Rendon,Manuel A. Ferreira,Willem H. Ouwehand,Nicole Soranzo

New gene functions in megakaryopoiesis and platelet formation

2011

Christian Gieger
Aparna Radhakrishnan
Ana Cvejic
Weihong Tang
Eleonora Porcu
Giorgio Pistis
Jovana Serbanovic-Canic
Ulrich Elling
Alison H. Goodall
Yann Labrune
Lorna M. Lopez
Reedik Mägi
Stuart Meacham
Yukinori Okada
Nicola Pirastu
Rossella Sorice
Alexander Teumer
Katrin Voss
Weihua Zhang
Ramiro Ramirez-Solis
Joshua C. Bis
David Ellinghaus
Martin Gögele
Jouke-Jan Hottenga
Claudia Langenberg
Peter Kovacs
Paul F. O'Reilly
So-Youn Shin
Tõnu Esko
Jaana Hartiala
Stavroula Kanoni
Federico Murgia
Afshin Parsa
Jonathan Stephens
Pim van der Harst
C. Ellen van der Schoot
Hooman Allayee
Antony Attwood
Beverley Balkau
François Bastardot
Saonli Basu
Sebastian E. Baumeister
Ginevra Biino
Lorenzo Bomba
Amélie Bonnefond
François Cambien
John Chambers
Francesco Cucca
Pio D’Adamo
Gail Davies
Rudolf A. de Boer
Eco J. C. de Geus
Angela Döring
Paul Elliott
Jeanette Erdmann
David Evans
Mario Falchi
Wei Feng
Aaron R. Folsom
Ian H. Frazer
Quince Gibson
Nicole L. Glazer
Christopher J. Hammond
Anna-Liisa Hartikainen
Susan R. Heckbert
Christian Hengstenberg
Micha Hersch
Thomas Illig
Ruth J. F. Loos
Jennifer Jolley
Kay-Tee Khaw
Brigitte Kühnel
Marie-Christine Kyrtsonis
Vasiliki Lagou
Heather Lloyd-Jones
Thomas Lumley
Massimo Mangino
Andrea Maschio
Irene Mateo Leach
Barbara McKnight
Yasin Memari
Braxton D. Mitchell
Grant W. Montgomery
Yusuke Nakamura
Matthias Nauck
Gerjan Navis
Ute Nöthlings
Ilja M. Nolte
David J. Porteous
Anneli Pouta
Peter P. Pramstaller
Janne Pullat
Susan M. Ring
Jerome I. Rotter
Daniela Ruggiero
Aimo Ruokonen
Cinzia Sala
Nilesh J. Samani
Jennifer Sambrook
David Schlessinger
Stefan Schreiber
Heribert Schunkert
James Scott
Nicholas L. Smith
Harold Snieder
John M. Starr
Michael Stumvoll
Atsushi Takahashi
W.H. Wilson Tang
Kent D. Taylor
Albert Tenesa
Swee-Lay Thein
Anke Tönjes
Manuela Uda
Sheila Ulivi
Dirk J. van Veldhuisen
Peter M. Visscher
Uwe Völker
H.-Erich Wichmann
Kerri L. Wiggins
Gonneke Willemsen
Tsun-Po Yang
Jing Hua Zhao
Paavo Zitting
John R. Bradley
George Dedoussis
Paolo Gasparini
Stanley L. Hazen
Andres Metspalu
Mario Pirastu
Alan R. Shuldiner
L. Joost van Pelt
Jaap Jan Zwaginga
Dorret I. Boomsma
Ian J. Deary
Andre Franke
Philippe Froguel
Santhi K. Ganesh
Marjo-Riitta Järvelin
Nicholas G. Martin
Christa Meisinger
Bruce M. Psaty
Tim D. Spector
Nicholas J. Wareham
Jan Willem N. Akkerman
Marina Ciullo
Panos Deloukas
Andreas Greinacher
Steve Jupe
Naoyuki Kamatani
Jyoti Khadake
Jaspal S. Kooner
Josef M. Penninger
Inga Prokopenko
Derek L. Stemple
Daniela Toniolo
Lorenz Wernisch
Serena Sanna
Andrew A. Hicks
Augusto Rendon
Manuel A. Ferreira
Willem H. Ouwehand
Nicole Soranzo

A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

Keywords:

Gene expression profiling
Genetic association
Locus (genetics)
Gene silencing
Genome-wide association study
Megakaryopoiesis
Gene
Population
Biology
Genetics
Genomics

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

354

Citations