The correlation analysis between type 2 diabetic nephropathy severity and thyroid function

Objective To analyze the relationship between thyroid function and grades of diabetic nephropathy(DN). Methods One hundred and twenty patients with definite DN were classified into the four groups, and forty patients with non- DN diabetic was NDN group. Their serum albumin, blood hemoglobin, serum potassium, functional parameters of thyroid and dependability to DN were analyzed. Results The plasma albumin ofⅢ,ⅣandⅤgroup were(41.3±3.6)g/L,(30.5±4.8)g/L and(28.3±5.9)g/L,which were lower than those of NDN group(F= 11.36,P< 0.05).24h urine protein of Ⅲ,ⅣandⅤwere(0.48±0.29)g,(1.86 ±0.54)g and(1.69±0.67)g,which were higher than those of group NDN(F= 7.12,P< 0.05). Triiodothyronine (T3)ofⅢ,ⅣandⅤgroup were(0.98±0.38)nmol/L,(0.75±0.41)nmol/L and(0.60±0.28)nmol/L,which were lower than those of NDN group(F= 7.64,P<0.05).Tetraiodothyronine(T4)of III,IV and V group were(6.06±1.76)nmol/L,(5.31±1.98)nmol/L and(4.65±1.87)nmol/L,which were lower than those of NDN group(F= 6.83,P<0.05).Free Triiodothyronine(FT3)ofⅢ,ⅣandⅤgroup were(4.37±2.12)pmol/L,(3.33±2.30) pmol/L and(2.91±1.82)pmol/L,which were lower than those of NDN group(F= 7.14,P< 0.05).Correlation analysis indicated that FT3 was an independent predictor for the severity of diabetic nephropathy. Conclusion In the patients with DNⅣ and Ⅴ,DN has attained a very severe status and the treatment of DN should be intensive. Key words: Diabetic nephropathies; Thyroid function