[D-lactate as a novel somnogenic factor?]

OBJECTIVE To evaluate an influence of intracerebral L-lactate concentration on sleep-wake cycle. MATERIAL AND METHODS Twenty adult male white rats preliminary implanted (under general anesthesia) with the electrodes for neocortical EEG and a single cannula to a lateral ventricle were used as subjects. A 5 µl bolus of either saline or a solution of sodium L- or D-lactate (0.1 mg, 0.2 M, Sigma-Aldrich) was injected through the cannula and followed by a 6-hr recording. RESULTS AND CONCLUSION Administration of L-lactate does not influence sleep-wake cycle of experimental animals. At the same time, its artificial optical analog D-lactate induces the significant (as compared to the control) decrease in wake (34.8% to 26.5%) and increase in slow wave sleep (57.4% to 69.2%). It has been suggested that D-lactate may be the antagonist of one or several L-lactate receptors.