Interpenetrating polysaccharide-based hydrogel: A dynamically responsive versatile medium for precisely controlled synthesis of nanometals.

Abstract Herein, we reported an interpenetrating polysaccharide-based hydrogel in which carboxymethyl chitosan (CMC) chains were physically dispersed throughout the thermoplastic elastomer gel network has been developed as a versatile platform for precisely controlled synthesis of nanometals. Results indicated the interpenetrated CMC chains could serve as multifunctional fillers for metal ions adsorption and stabilization while the thermally reconfigurable agarose (Agar) gel medium provides three-dimensional semi-solid framework for entrapping and recollecting of the fabricated nanometals. Specifically, the CMC chains were found to strongly coordinate with silver ions as a dynamically responsive metal-biopolymer complex within the bulk gel network as confirmed by the enhanced mechanical properties and regulated shape memory performances. Moreover, by varying CMC concentrations and coupling with a layer-stacking approach, multiple biochemical gradients could be facilely generated for in-situ synthesis of silver nanoparticles, achieving a narrow size of ~7 nm, confined sphere-shape and high concentrations. The monodispersed nanometals are confirmed to be highly active (e.g., considerable catalytic performance), and which could be easily recycled from the bulk gel system via a heating treatment. Thus, this work would provide a generic methodology for the multifunctional metallogel assembly and great possibility for controllable and largescale synthesis of noble nanometals toward biomedical applications.